Extracts of Bryophyllum pinnatum and Chasmanthera dependens which are tropical plants and indigenous Nigerian medicinal plants, is being investigated for the production of topical herbal skin ointments. The study will include the characterization of bioactive compounds from these plants which have anti-skin ulcer, analgesic antimicrobial, anti-inflamatory and antioxidant activity as well as formulating topical herbal medications for the ailments. Thus B.pinnatum and C.dependends samples will be extracted and fractionated. Extracts of B. pinnatum will be used to formulate standardized topical anti-ulcer, antibiotic and antioxidant ointments. With C. dependens extracts, standardized topical analgesic, anti-inflammatory and antioxidant ointments will be produced. Crude extracts, fractions as well as the herbal formulations will be tested for activity: ulcer healing, anti-oxidant activity, anti-inflammatory activity, analgesic activity.This project is on-going.